A billoard from the AIDS Healthcare Foundation (AHF) is seen on Sunset Boulevard in Hollywood, California on May 29, 2018 warning of a drug resistant Gonorrhea. – A billboard on Sunset Boulevard in Hollywood screams out a stark warning: “drug-resistant gonorrhea alert!” Sexually transmitted diseases have made an alarming resurgence across the US, where 2016 saw a record two million cases of chlamydia, gonorrhea and syphilis, including 628 cases of congenital syphilis. But California, the most populous US state, stands out for its willingness to tackle the crisis head-on, with cases of the three ailments up 45 percent in 2017 from five years ago. (Photo by Frederic J. BROWN / AFP) / TO GO WITH AFP STORY by Javier TOVAR, “California on front line as STDs run rampant in US” (Photo credit should read FREDERIC J. BROWN/AFP via Getty Images)